Entresto: Uses, Dosage, Side Effects, Price and Precautions

Entresto is a medication used to treat heart failure with reduced ejection fraction, a condition where the heart muscle does not contract effectively, leading to inadequate pumping of blood. It contains a combination of two active ingredients: sacubitril and valsartan. Sacubitril helps to increase the levels of certain natural substances in the body that widen blood vessels and reduce the workload on the heart, while valsartan works by relaxing blood vessels, reducing blood pressure, and improving heart function. In this article, we will discover Entresto’s uses, benefits, precautions and side effects of Entresto.

Uses of Entresto Tablet

Entresto is primarily used for the management of heart failure with reduced ejection fraction (HFrEF), a condition in which the heart muscle does not contract effectively, leading to inadequate pumping of blood.

By using Entresto, patients with heart failure with reduced ejection fraction may experience the following benefits:

1. Symptom Improvement

Entresto can help alleviate symptoms such as shortness of breath, fatigue, and fluid retention, allowing patients to engage in daily activities with greater ease.

2. Reduced Hospitalizations

Studies have shown that Entresto can decrease the risk of hospitalization due to heart failure compared to traditional treatments. It helps to stabilize heart function and reduce the likelihood of acute exacerbations.

3. Prolonged Survival

Entresto has been shown to improve overall survival rates in patients with heart failure compared to other medications. It helps to slow disease progression and improve long-term outcomes.

4. Personalized Treatment

The use of Entresto is determined by a healthcare professional based on an individual’s specific condition, medical history, and response to other heart failure medications. It is part of a comprehensive treatment plan tailored to each patient’s needs.

Entresto is specifically indicated for heart failure with reduced ejection fraction (HFrEF) and may not be suitable or have sufficient evidence of efficacy in other types of heart failure. It is always best to consult with a healthcare professional for a comprehensive evaluation and personalized treatment plan.

Benefits of Entresto

The benefits of Entresto include:

• Improved symptoms: Entresto can alleviate symptoms of heart failure, such as shortness of breath and fatigue, allowing patients to engage in daily activities with greater ease.
• Reduced hospitalizations: Studies have shown that Entresto can reduce the risk of hospitalization due to heart failure compared to traditional treatments.
• Increased survival: Entresto has been shown to improve overall survival rates in patients with heart failure when compared to other medications.

Entresto Side Effects

Here are some of the potential side effects of Entresto:

• Hypotension (Low Blood Pressure): Entresto can cause a drop in blood pressure, leading to symptoms such as dizziness, lightheadedness, and fainting.
• Hyperkalemia (High Potassium Levels): Entresto may cause an increase in potassium levels in the blood, resulting in symptoms such as weakness, fatigue, irregular heartbeat, or muscle cramps. 
• Renal Impairment: Entresto may affect kidney function, particularly in individuals with pre-existing kidney disease or reduced kidney function.
• Angioedema: Although rare, Entresto can cause angioedema, a serious allergic reaction characterized by swelling of the face, lips, tongue, or throat. Immediate medical attention should be sought if symptoms of angioedema develop.
• Hypersensitivity Reactions: Some individuals may experience allergic reactions to Entresto, resulting in symptoms such as rash, itching, or hives.
• Impaired Liver Function: Entresto can cause mild to moderate increases in liver enzymes, which may indicate impaired liver function.
• Cough: A dry, non-productive cough may occur as a side effect of Entresto.
• Diarrhea: Some individuals may experience diarrhea while taking Entresto.
• Other Side Effects: Additional side effects that may occur, although less commonly, include headache, fatigue, dizziness, increased heart rate, and changes in taste.

It is important to note that not all individuals will experience these side effects, and the severity and frequency of side effects may vary from person to person. If you experience any concerning or persistent side effects while taking Entresto, it is crucial to inform your healthcare professional for proper evaluation and guidance.

Price of Entresto

The cost of Entresto can vary depending on factors such as the country, dosage, and insurance coverage. It is generally considered a relatively expensive medication. To obtain accurate pricing information, it is recommended to consult a local pharmacy or healthcare provider.

Precautions

Here are the precautions to consider when using Entresto:

• Medical History: Inform your healthcare professional about your complete medical history, including any previous or existing conditions, such as kidney problems, liver disease, or a history of angioedema (swelling of the face, lips, tongue, or throat).
• Allergies: Inform your doctor about any known allergies or adverse reactions to medications, including previous reactions to ACE inhibitors or ARBs, as Entresto contains valsartan, an ARB.
• Pregnancy and Breastfeeding: Entresto is not recommended during pregnancy as it may harm the developing fetus. It is also not recommended while breastfeeding, as it is unknown whether Entresto passes into breast milk. 
• Dosage and Administration: Follow the prescribed dosage and administration instructions provided by your healthcare professional. Do not alter the dosage or stop taking Entresto without consulting your doctor, as abrupt discontinuation may worsen heart failure symptoms.
• Blood Pressure Monitoring: Regularly monitor your blood pressure as directed by your healthcare professional. Entresto may cause low blood pressure, especially at the beginning of treatment or when the dosage is increased. 
• Kidney Function: Entresto may affect kidney function, especially in patients with pre-existing kidney problems. Your healthcare professional may monitor your kidney function through blood tests and adjust the dosage accordingly.
• Drug Interactions: It is advisable to Inform your healthcare consultant about all medications, supplements, and herbal products you are taking.
• Angioedema: Entresto may rarely cause angioedema, a serious allergic reaction characterized by swelling of the face, lips, tongue, or throat. Seek immediate medical attention if you experience symptoms of angioedema.
• Regular Follow-up: Regularly follow up with your healthcare professional for monitoring of your condition, evaluation of treatment effectiveness, and potential adjustments to your medication regimen.

Remember, these precautions are general guidelines, and it is important to consult with your healthcare professional for personalized advice and guidance regarding the use of Entresto, considering your specific medical condition and individual factors.

Frequently Asked Questions (FAQs)